RanGAP2 Mediates Nucleocytoplasmic Partitioning of the NB-LRR Immune Receptor Rx in the Solanaceae, Thereby Dictating Rx Function W OA
نویسندگان
چکیده
Wladimir I.L. Tameling,a,1 Claudia Nooijen,a Nora Ludwig,a Marta Boter,b Erik Slootweg,c Aska Goverse,c,d Ken Shirasu,b and Matthieu H.A.J. Joostena,d a Laboratory of Phytopathology, Wageningen University, 6708 PB Wageningen, The Netherlands b Sainsbury Laboratory, John Innes Centre, Norwich NR4 7UH, United Kingdom c Laboratory of Nematology, Wageningen University, 6708 PB Wageningen, The Netherlands d Centre for BioSystems Genomics, 6700 AB Wageningen, The Netherlands
منابع مشابه
RanGAP2 mediates nucleocytoplasmic partitioning of the NB-LRR immune receptor Rx in the Solanaceae, thereby dictating Rx function.
The potato (Solanum tuberosum) nucleotide binding-leucine-rich repeat immune receptor Rx confers resistance to Potato virus X (PVX) and requires Ran GTPase-activating protein 2 (RanGAP2) for effective immune signaling. Although Rx does not contain a discernible nuclear localization signal, the protein localizes to both the cytoplasm and nucleus in Nicotiana benthamiana. Transient coexpression o...
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Plant nucleotide-binding (NB) and leucine-rich repeat (LRR) receptors mediate effector-triggered immunity. Two major classes of NB-LRR proteins are involved in this process, namely, toll-interleukin receptor (TIR)-NB-LRR and coiled coil (CC)-NB-LRR proteins. Recent reports show that some of the TIR-NB-LRRs and CC-NB-LRRs localize to the cytoplasm and nucleus. Equilibrium between these pools is ...
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Plant nucleotide binding and leucine-rich repeat (NB-LRR) proteins contain a region of homology known as the ARC domain located between the NB and LRR domains. Structural modeling suggests that the ARC region can be subdivided into ARC1 and ARC2 domains. We have used the potato (Solanum tuberosum) Rx protein, which confers resistance toPotato virus X (PVX), to investigate the function of the AR...
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Genes encoding plant nucleotide-binding leucine-rich repeat (NB-LRR) proteins confer dominant resistance to diverse pathogens. The wild-type potato NB-LRR protein Rx confers resistance against a single strain of potato virus X (PVX), whereas LRR mutants protect against both a second PVX strain and the distantly related poplar mosaic virus (PopMV). In one of the Rx mutants there was a cost to th...
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